How important is panel layout and composition in a comic strip, and what are some basic principles to follow?

Panel layout and composition are crucial as they guide the reader's eye, control the pacing of the story, and enhance the delivery of the joke or narrative. Basic principles include using a consistent grid (e.g., three horizontal panels for classic strips), varying panel sizes to emphasize key moments, and using leading lines or character gazes to direct attention. Ensure there's clear visual flow from one panel to the next, avoiding clutter or confusion.